When using Acnezine Acne Treatment, there are a few things you will want to avoid in order to guarantee maximum results, and to minimize problems with irritation. Always use a sunscreen to avoid unnecessary skin exposure. Acnezine is for external use only and you should avoid contact with the eyes, mouth and lips. Be careful with using Acnezine with other topical acne medications. An increased amount of dryness and skin irritation will occur. Redness, burning, itching, peeling or swelling may occur, but can be reduced with less usage. As with any other type of medication, following your doctor’s directions are also essential.